STEP 1: Drug reactions
Terms
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- Urinary Retention
-
Tricyclics, Antipsychotics
Anticholinergics that block sympathetic detrusor contraction
Synpathomimetics
Increase tone of internal urethral sphincter - Orthostatic hypertension
-
Alpha-1 blockers
= zosins - cutaneous flushing
-
niacin (B3)
Increases HDL, lowers LDL by blocking fat catabolism
-
1.Constipation and AV block
2. AV block -
1.Ca++ channel blockers:
Verapamil, diltiazem
2. B Blockers - Decreases symptoms of hypoglycemis (ie: not good for diabetics)
- B Blockers
- Block epinephrine-induced gluconeogenesis and glycogenolysis
- B Blockers
- Stimulates Cellular K UPTAKE
- insulin
- Exacerbate hyperglycemia in diabetics
-
Loop and Thiazide diuretics:
--> low K = decreased insulin release and decreased cell response to insulin - Dry cough
-
ACE inhibitors
--> increased bradykinin - Reflex tachycardia
-
a-1 blockers (zosins) and hydralazine
- Lupus-like reactions
- Hydralazine (vasodilator)
- Acute tubular nephrosis
- Aminoglycosides and Amph B
-
Low: K
High: Uric acid, blood sugar
- Thiazide and loop (furosemide, bumetamide) diuretics
- Combo that causes ototoxicity
- Loop diuretic + aminoglycoside
-
Ototoxicity, Nephrotoxicity +:
1. Teratogen
2. Thrombophebitis -
1. Aminoglycosides
2. Vanc - Redman syndrome
- Vancomycin
- Grey baby syndrome
-
Chloramphenicol
Babies have insufficient UDP-glucoronyl transferase to clear the toxic metabolites - CNS toxicity, rash, seizures
- Imipenem and Carbepenem
- Lack of Fat soluble vitamin absorption
- Bile resins (chole's)
- Stephens Johnson Syndrome
- Lamotragine, phenytion, sulfonamides, penicillins
-
Stephens Johnson's
(combo) - Lamotragine + Na Valproate
- Respiratory Depression
- Benzo's, Barb's, opiates, alcohol
- Gout
-
Thiazides
- Dialated Cardiomyopathies
-
-rubicins
(anthracyclins: cancer drugs that intercalate DNA) -
N/V
HA
Dizziness
Confusion
V TACH -
Digoxin
Common side effect tested because of narrow therapeutic index - Blocks fetal growth and causes anemia
- Ribavirin (antivirus for RSV and Hep C)
- Like being drunk
-
Amantidine
Used to be used as antiviral, now commonly associated with PARKINSON's - Flushing, SOB, Chest Pain
-
Adenosine
Causes transient AV block, antiarrythmic
Think SVTs
Effects can be blunted in individuals that take in a lot of caffeine - myopathies
-
Statins and Fibrates
(esp when used as combo)