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Glossary of STEP 1: Drug reactions

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Created by evrigsby

Urinary Retention
Tricyclics, Antipsychotics
Anticholinergics that block sympathetic detrusor contraction

Synpathomimetics
Increase tone of internal urethral sphincter



Orthostatic hypertension
Alpha-1 blockers
= zosins
cutaneous flushing
niacin (B3)
Increases HDL, lowers LDL by blocking fat catabolism


1.Constipation and AV block

2. AV block

1.Ca++ channel blockers:
Verapamil, diltiazem

2. B Blockers


Decreases symptoms of hypoglycemis (ie: not good for diabetics)
B Blockers
Block epinephrine-induced gluconeogenesis and glycogenolysis
B Blockers
Stimulates Cellular K UPTAKE
insulin
Exacerbate hyperglycemia in diabetics
Loop and Thiazide diuretics:
--> low K = decreased insulin release and decreased cell response to insulin
Dry cough
ACE inhibitors
--> increased bradykinin
Reflex tachycardia
a-1 blockers (zosins) and hydralazine

Lupus-like reactions
Hydralazine (vasodilator)
Acute tubular nephrosis
Aminoglycosides and Amph B
Low: K
High: Uric acid, blood sugar




Thiazide and loop (furosemide, bumetamide) diuretics
Combo that causes ototoxicity
Loop diuretic + aminoglycoside
Ototoxicity, Nephrotoxicity +:

1. Teratogen
2. Thrombophebitis


1. Aminoglycosides
2. Vanc
Redman syndrome
Vancomycin
Grey baby syndrome
Chloramphenicol

Babies have insufficient UDP-glucoronyl transferase to clear the toxic metabolites

CNS toxicity, rash, seizures
Imipenem and Carbepenem
Lack of Fat soluble vitamin absorption
Bile resins (chole's)
Stephens Johnson Syndrome
Lamotragine, phenytion, sulfonamides, penicillins
Stephens Johnson's
(combo)
Lamotragine + Na Valproate
Respiratory Depression
Benzo's, Barb's, opiates, alcohol
Gout
Thiazides

Dialated Cardiomyopathies
-rubicins

(anthracyclins: cancer drugs that intercalate DNA)

N/V
HA
Dizziness
Confusion

V TACH




Digoxin

Common side effect tested because of narrow therapeutic index

Blocks fetal growth and causes anemia
Ribavirin (antivirus for RSV and Hep C)
Like being drunk
Amantidine
Used to be used as antiviral, now commonly associated with PARKINSON's
Flushing, SOB, Chest Pain
Adenosine
Causes transient AV block, antiarrythmic
Think SVTs

Effects can be blunted in individuals that take in a lot of caffeine



myopathies
Statins and Fibrates
(esp when used as combo)

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