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Glossary of Oncogenes and Tumor Markers

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Created by deonnaj

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abl
CML
c-myc
Burkitt's Lymphoma
bcl-2
Follicular and undifferentiated lymphomas (apoptosis inhibitor)
erb-B2
Breast, ovarian, and gastric carcinoma
ras
Colon Carcinoma, Follicular thyroid carcinoma
L-myc
Lung Tumor

L for lung

ret
MEN II and III, papillary carcinoma of the thyroid
c-kit
Gastrointestinal stromal tumor
Rb
Retinoblastoma, osteosarcoma (13q)
BRCA 1
Breast and ovarian carcinoma (17q)

plays role in gene repair and transcription

p53
Most human cancers, Li-Fruaumeni Syndrome
p16
Melanoma (9p)
APC
colorectal cancer, Gardners (11p)
NF1
Neurofibromatosis type 1 (18q)
NF2
Neurofibromatosis 2 (22q)
DPC
Pancreatic Cancer (18q)

Deleted in Pancreatic Cancer

DCC
Colon Cancer (18q)

Deleted in Colon Cancer

PSA
Prostate Specific antigen

Used for screening

Prostatic acid phosphatase
Prostate carcinoma
CEA
Carinoembryonic antigen
70% of colorectal and pancreatic cancers (nonspecific; monitor recurrence)
alpha fetoprotein
Fetus, hepatocellular carcinoma, yolk sac tumor aka endodermal sinus tumor
B-hCG
Hytadidiform moles, Choriocarcinoas
CA-125
ovarian, malignant epithelial tumors, peritoneal irritation
Alkaline Phosphatase
Metastases to bone, obstructive biliary disease, Pagets
Bombesin
neuroblastoma, lung, gastric carcinoma
TRAP
tartrate-resistant acid phosphatase

Hairy Cell leukemia

CA 19-9
Pancreatic adenocarcinoma
CA-15-3
Pancreatic Adenocarcinoma

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