Glossary of NDBE Physiology
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- Where are the 2 places that FA OXIDATION does not occur?
What organelle does FA oxidation occur
- Brain and Mature RBC's
- What is the one place where the KREBS cycle and Oxidative Phosphorylation does not occur?
What organelle in the cell does the KREB cycle occur?
- Mature RBC's
- What is the one place where protein synthesis does not occur?
- Mature RBC's
- Fatty Acid (LIPID) synthesis occures primarily in what 2 tissue types
- Liver and Adipose Tissues
- Gluconeogenesis (synthesis of glucose) primarily occurs in what 2 tissue types
- Liver and Kidney; Partially in the mitochondria and partially in the cytosol (like urea cycle)
- Heme synthesis occurs where?
- Bone Marrow
- Hexose Monophosphate Shunt (HMP-shunt) occures in what 5 sites and where in the cell
- liver, adipose, rbc, adrenal cortex, mammary gland
- Amino Acid Synthesis// Breakdown primarily occurs in
- Urea Synthesis occurs where and in what/which organelle(s)
- Liver; Part occurs in the Mitochondria and the other part in the cytosol
- Cholesterol and Bile synthesis occurs where
- Steroid and Hormone Synthesis occurs where (2 places)
- Adrenal CORTEX and Gonads
- Formation of Acetyl CoA occurs where?
- What happen in the Golgi
- Synthesis and Packaging of Complex molecules like:
- Glycolysis occurs where in the cell
What also occurs there
-FA synthesis, Protein Synthesis, HMP shunt, Part of Urea and Gluconeogenesis pathway
- Molecules are degraded in this organelle
DNA and RNA synthesis occurs here?
- Glucose above this level will lead to glucose in the urine
- ENDOcytosis requires ATP. T or F
Proteins are ENDOcytosed
- BLOOD PRESSURE
- BLOOD PRESSURE
- Blood Pressure is the measure of what?
- Brachial Artery Pressure
- What is the normal BP of an adult
- Out of the #'s 120 and 80, which is Systolic and which is Diastolic?
- 120= Systolic
- What does systolic mean?
What does diastolic mean?
- Systolic= Contraction
-Arterial Pressure @ Contraction (thus it is a higher number b/c there is more pressure)
-Arterial pressure when cardiac ventricles are relaxed (lower number, less pressure)
- Hardening of Arteries is know clinically as:
- What type of blood pressure would one expect to see in a sperson w/ Athersclerosis
- Higher Systolic and Lower Diastolic
-Ventricular Walls are RIGID thus less flexible of vessels so when the ventricles contract A LOT of pressure is seen (b/c or more resistance of the vessels to contract) but when it is diastole there is a DRAMATIC drop (extreme contraction pressure to lower pressure- less resistance)
- Aortic Regurgitation is when blood seeps back into the the aorta due to a faulty aortic valve. What do you expect to see in regards to systole and diastole?
- Low Diastole due to blood running back (less blood thus less pressure) BUT HIGH Systole b/c of added volume that the heart has to pump w/ each beat to meet the demands of the body
- What is the ductus arteriosis?
- Shunt during fetal development in which blood flow from the pulmonary artery directly to the aorta
(Fetus does not oxygenate its own blood)
- What is the condition called if the ductus arteriosis never closes @ birth
How will blood flow?
What is the result
- Patent Ductus Arteriosis
OXYGENATED Blood from the AORTA will flow into the Pulmonary Artery producing High CO (which means more blood in the aorta, which means a HIGH Systolic PRESSURE)
Diastolic pressure is LOWER than normal b/c there is little resistance to blood flowing from aorta into pulmonary artery
- Mean Blood pressure in major arteries is about ____ @ AORTA and mean blood pressure near the vena cava is ____.
Why is this important?
- 100 ; 0
Blood pressure difference is why blood flows (blood flows from a higher pressure to a lower pressure)
- If the mean blood pressure were 100 in all the circulatory system what would happen
- NO BLOOD WOULD FLOW (must have differenc)
- In a standing person I would expect to see a higher mean blood pressure in the brachial artery/arteries of the feet?
- Arteries of the Feet
- Korotkoff sounds are what is heard when taking blood pressure. The first sound heard is the ___ pressure and they when the sounds disappear this is called the ___ pressure
- Systolic; Diastolic
- What happens if BP is too high?
- Blood vessel may break and cause a stroke (blood loss to the brain)
- What two factors control BP?
-Increases in these will cause what?
- Peripheral Resistance and Cardiac Output
-Increases in either of these will cause an INCREASE in BP
- Peripheral Resistance is controlled by ____.
What is the equation for CO
- Vessel Constriction
CO= SV * HR
-Generally 5-6 liters/min
- How does Peripheral Resistance increase BP?
-At what level of arterial circulation does this occur?
- Impedes Blood Flow by Vasoconstriction - blood builds up in arteries (where BP is measure)
-This occurs at the Arteriole level
- What is the Mean Circulatory Filling Pressure? What is its value
- BP that one would find if the heart were to stop (5-10mm Hg)
- In a normal individual excercising there would be a rise in CO. You would see a rise in ___ but not in ___.
- Systole=Higher BP; Diastole
- In atheletes one will see a rise in ___ but LOW___.
- Rise in CO; LOW BP (b/c they have trained there bodies to have a relatively low vascular resistance during excercise)
- Increasing Blood volume will increase BP by increasing ___.
Increase Blood Volume= Increase CO= Increase BP
- What is the normal adult Blood volume?
- 5-6 liters
- How do Na and H20 correlate with each other.
- Water follows Na so an increase in Na will increase H20 retention
- Na is found in the ___. It is its most abundant electrolyte
- BP, Peripheral Resistance, CO and Blood volume all are under POSITIVE FEEDBACK control. T or F.
- FALSE: NEGATIVE FEEDBACK CONTROL
Increase in BP will lead to a DECREASE in homeostatic BP
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