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Glossary of Lab Dx final

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Iron deficiency :Peripheral smear morphology?
microcytic, hypochromic
Iron deficiency :MCV?
low
Iron deficiency :basophilic stippling?
no
Iron deficiency :serum iron?
low
Iron deficiency :TIBC?
high
Iron deficiency :Serum iron/TIBC?
low <10% then definitely iron defic.
Iron deficiency :ferritin?
under 10, iron defic
Iron deficiency :soluble transferrin receptor?
increased
Iron deficiency :absorption site?
duodenum
Beta Thalessemia trait :?
Beta Thalessemia trait
Beta Thalessemia trait :Peripheral smear morphology?
microcytic
Beta Thalessemia trait :MCV?
low
Beta Thalessemia trait :basophilic stippling?
y
Beta Thalessemia trait :Hgb A2 Assay?
positive
Alpha thalessemia trait :?
Alpha thalessemia trait
Alpha thalessemia trait :Peripheral smear morphology?
microcytic
Alpha thalessemia trait :MCV?
low
anemia of chronic disease :?
anemia of chronic disease
anemia of chronic disease :Peripheral smear morphology?
usually normocytic, microcytic (rarely)
anemia of chronic disease :Reticulocyte count?
Low
anemia of chronic disease :MCV?
normal
anemia of chronic disease :serum iron?
low
anemia of chronic disease :TIBC?
high
anemia of chronic disease :Serum iron/TIBC?
>10%
anemia of chronic disease :ferritin?
normalish
anemia of chronic disease :soluble transferrin receptor?
decreased
sideroblastic anemia :?
sideroblastic anemia
sideroblastic anemia :Peripheral smear morphology?
microcytic
sideroblastic anemia :MCV?
low
aplastic anemia :?
aplastic anemia
aplastic anemia :Peripheral smear morphology?
normocytic
aplastic anemia :Reticulocyte count?
Low
aplastic anemia :MCV?
normal
aplastic anemia :Marrow?
hypoplastic
aplastic anemia :platelets?
low
aplastic anemia :PMN's?
low
aplastic anemia :tx?
transplant
pure red cell aplasia :?
pure red cell aplasia
pure red cell aplasia :Peripheral smear morphology?
normocytic
pure red cell aplasia :Reticulocyte count?
stupid low
pure red cell aplasia :MCV?
normal
pure red cell aplasia :platelets?
normal
pure red cell aplasia :PMN's?
normal
pure red cell aplasia :caused by?
dilantin, parvovirus, thymoma, PRCA
pure red cell aplasia :tx?
roids
myelofibrosis :?
myelofibrosis
myelofibrosis :Peripheral smear morphology?
normocytic
myelofibrosis :Reticulocyte count?
Low
myelofibrosis :MCV?
normal
myelofibrosis :Marrow?
fibrosis
myelofibrosis :physcal exam findings?
big ass spleen
myelodysplasia :?
myelodysplasia
myelodysplasia :Peripheral smear morphology?
normocytic
myelodysplasia :Reticulocyte count?
Low
myelodysplasia :MCV?
normal
myelodysplasia :Marrow?
variable
myelodysplasia :iron staining?
ringed sideroblasts
myelophtisic anemia :?
myelophtisic anemia
myelophtisic anemia :Peripheral smear morphology?
normocytic
myelophtisic anemia :Reticulocyte count?
Low
myelophtisic anemia :MCV?
normal
myelophtisic anemia :Marrow?
marrow replacement
B12 deficiency :?
B12 deficiency
B12 deficiency :Peripheral smear morphology?
macrocytic, multilobed polys
B12 deficiency :MCV?
high
B12 deficiency :absorption site?
terminal ileum
B12 deficiency :foods containing nutrient?
meat, animal products
B12 deficiency :serum b12?
low
folate deficiency :?
folate deficiency
folate deficiency :Peripheral smear morphology?
macrocytic, multilobed polys
folate deficiency :MCV?
high
folate deficiency :absorption site?
jejunum
folate deficiency :foods containing nutrient?
veggies
folate deficiency :red cell folate?
low
folate deficiency :serum folate?
low, but easily altered by one meal
Bleeding :?
Bleeding
Bleeding :Reticulocyte count?
High
Hemolytic anemia :?
Hemolytic anemia
Hemolytic anemia :Reticulocyte count?
up
B12 deficiency due to low IF :?
B12 deficiency due to low IF
B12 deficiency due to low IF :schilling?
no radioactive urine, radioactive after IF
Normocytic anemia and low reticulocyte count :?
Normocytic anemia and low reticulocyte count
Normocytic anemia and low reticulocyte count :initial tests?
Do a bone marrow aspirate and biopsy, possibly cytogenetics
Hemolytic anemia :bilirubin?
up (unconjugated)
Hemolytic anemia :LDH?
elevated (nonspecific)
Hemolytic anemia :chromium 51 survival?
decreased
bleeding :bilirubin?
no effect
bleeding :LDH?
no effect
bleeding :chromium 51 survival?
no effect
warm IgG :?
warm IgG
warm IgG :intra or extra-vascular?
extra
warm IgG :haptoglobin?
no effect
warm IgG :rouleaux?
n
cold IgM :?
cold IgM
cold IgM :intra or extra-vascular?
intra
cold IgM :haptoglobin?
low
cold IgM :rouleaux?
y
pseudoerythrocytosis :?
pseudoerythrocytosis
pseudoerythrocytosis :HCT?
up
pseudoerythrocytosis :plasma volume?
down
pseudoerythrocytosis :which cell lines hyperlastic??
none
pseudoerythrocytosis :big spleen??
no
pseudoerythrocytosis :casued by high EPO?
no
2ndary erythrocytosis :?
2ndary erythrocytosis
2ndary erythrocytosis :HCT?
up
2ndary erythrocytosis :plasma volume?
no effect
2ndary erythrocytosis :which cell lines hyperlastic??
red
2ndary erythrocytosis :big spleen??
no
2ndary erythrocytosis :casued by high EPO?
yes
polycythemia vera :?
polycythemia vera
polycythemia vera :HCT?
up
polycythemia vera :plasma volume?
no effect
polycythemia vera :which cell lines hyperlastic??
red, wbc, platelets
polycythemia vera :big spleen??
yes
polycythemia vera :casued by high EPO?
EPO independent
Pelger Huet :abnormality?
bilobed PMN
May Hegglin :?
May Hegglin
May Hegglin :abnormality?
basophilic inclusions in WBC
chediak Higashi :?
chediak Higashi
chediak Higashi :abnormality?
giant neutrophil granules, faulty lysosmes
Alders :?
Alders
Alders :abnormality?
deep purple granules, mucopolysaccharide disorder
Maroteaux Lamy :?
Maroteaux Lamy
Maroteaux Lamy :abnormality?
Red-violet granules and lymphocyte vacuoles
Erlichiosis :?
Erlichiosis
Erlichiosis :abnormality?
?? Caused by rickettsia, ticks
Dohle Bodies :?
Dohle Bodies
Dohle Bodies :abnormality?
1-2 micron oval blue RER fragments
CML :?
CML
CML :Anemia?
no
CML :RBC morphology?
no change
CML :WBC?
>100K
CML :Other cells?
up baso's and eosinos
CML :>5% myelocytes or younger?
Yes
CML :LAP?
low
CML :Marrow?
myeloid hyperplasia, B&E
CML :Splenomegaly?
yes
CML :t(9:22)?
yes
Myelofibrosis :Anemia?
yes
Myelofibrosis :RBC morphology?
teardrop and nucleated
Myelofibrosis :WBC?
maybe up
Myelofibrosis :Other cells?
no change
Myelofibrosis :>5% myelocytes or younger?
possible
Myelofibrosis :LAP?
variable
Myelofibrosis :Splenomegaly?
yes
Myelofibrosis :t(9:22)?
no
Leukemoid :?
Leukemoid
Leukemoid :Anemia?
no
Leukemoid :RBC morphology?
no change
Leukemoid :WBC?
30-40K
Leukemoid :Other cells?
no change
Leukemoid :>5% myelocytes or younger?
no
Leukemoid :LAP?
high
Leukemoid :Marrow?
myeloid hyperplasia
Leukemoid :Splenomegaly?
no
Leukemoid :t(9:22)?
no
CLL :?
CLL
CLL :abnormal cell type?
B
CLL :CD5+?
yes
Mono :?
Mono
Mono :abnormal cell type?
B
Hairy cell leukemia :?
Hairy cell leukemia
Hairy cell leukemia :abnormal cell type?
B
Hairy cell leukemia :splenomagaly?
fuckin huge
Hairy cell leukemia :CD5+?
no
Hairy cell leukemia :cytopenia type?
pancytopenia (& lymphocytosis)
Hairy cell leukemia :diagnostic test?
tartrate resistant acid phosphatase, TRAP
AML :?
AML
AML :population?
adult
AML :cytopenia type?
neutropenia, also could have elevated WBC (myeloblasts)
ALL :?
ALL
ALL :population?
children
neutropenia :?
neutropenia
neutropenia :1st step in dx of host defense disorder?
WBC and diferential
B cell disorder :?
B cell disorder
B cell disorder :1st step in dx of host defense disorder?
quantitative Ig's
Complement deficiency :?
Complement deficiency
Complement deficiency :1st step in dx of host defense disorder?
CH50, C3, if bad then quantitative C1-9
T cell disorder :?
T cell disorder
T cell disorder :1st step in dx of host defense disorder?
quantitative T and B lymphocytes, skin test to recall antigens
early complement deficiency :?
early complement deficiency
early complement deficiency :infection type?
pyogenic
late complement deficiency :?
late complement deficiency
late complement deficiency :infection type?
neisseria
platelet problem :Physical exam findings?
petechiae
clotting factors :?
clotting factors
clotting factors :Physical exam findings?
echymosis, joint bleeding
vWD :?
vWD
vWD :Physical exam findings?
joint bleeding
vasculitis :?
vasculitis
vasculitis :Physical exam findings?
palpable purpura
XII and XI :?
XII and XI
XII and XI :what activates in PTT?
kaolin
disorder of: XII, XI, IX, VIII, X, V, II, fibrinogen :?
disorder of: XII, XI, IX, VIII, X, V, II, fibrinogen
disorder of: XII, XI, IX, VIII, X, V, II, fibrinogen :which test?
PTT
heparin :?
heparin
heparin :which test?
PTT
Intrinsic pathway :?
Intrinsic pathway
Intrinsic pathway :which test?
PTT
extrinsic pathway :?
extrinsic pathway
extrinsic pathway :which test?
PT
add trhomboplastin to activate VII :?
add trhomboplastin to activate VII
add trhomboplastin to activate VII :which test?
PT
kaolin to activate XII and XI :?
kaolin to activate XII and XI
kaolin to activate XII and XI :which test?
PTT
VII, X, V, II, fibrinogen :?
VII, X, V, II, fibrinogen
VII, X, V, II, fibrinogen :which test?
PT
hemophilia A :?
hemophilia A
hemophilia A :deficiency?
VIII
Hemophilia B :?
Hemophilia B
Hemophilia B :deficiency?
IX (christmas disease....but it's in Jews!)
loose fibrin :?
loose fibrin
loose fibrin :deficiency?
XIII
clotting factors :Vd?
40 ml/kg
I :?
I
I :vitamin K??
no
I :PT?
yeah (fibrinogen)
I :PTT?
yeah (fibrinogen)
I :made in liver??
yeah (fibrinogen)
I :coumadin effects??
no
I :protein C & S inhibit?
no
II :?
II
II :vitamin K??
yep
II :PT?
yes
II :PTT?
yes
II :made in liver??
yes
II :coumadin effects??
yes
II :protein C & S inhibit?
no
II :cryoprecipitate?
no
II :prothombin complex concentrates?
yes
III :?
III
III :vitamin K??
no
III :PT?
no
III :PTT?
no
III :made in liver??
no
III :coumadin effects??
no
III :protein C & S inhibit?
no
IV :?
IV
IV :vitamin K??
it's friggin calcium
IV :PT?
it's friggin calcium
IV :PTT?
no
IV :made in liver??
no

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